COMPATIBILITY SCREENING OF VIDAGLIPTIN WITH IONIC AND NON-IONIC POLYMERIC EXCIPIENTS FOR THE DESIGN OF EXTENDED RELEASE DELIVERY SYSTEM
نویسندگان
چکیده
Studies of drug-polymer compatibility play an important role in the preformulation stage for development pharmaceutical dosage forms. The potential physical and chemical interactions between drugs polymer can affect nature, stability bioavailability form as a result therapeutic response clinical phase. present study reveals thermal spectroscopic mixtures Vildagliptin (VDG) HPMC combination with cationic polymers chitosan, anionic NaCMC nonionic PEO extended release (ER). In first phase study, differential scanning calorimeter (DSC) was used tool to detect any interaction. next phase, Fourier Transform Infrared Spectroscopy (FT-IR) technique confirm investigate type possible components. both cases, data revealed that analysed polymeric excipients did not show on VDG. Results indicated suitability K4M hydrophilic matrix polymers, non-ionic preparation formulation
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ژورنال
عنوان ژورنال: International journal of advanced research
سال: 2021
ISSN: ['2707-7802', '2707-7810']
DOI: https://doi.org/10.21474/ijar01/12671